We study the interactions between pathogens and the innate immune system.
Infection is a constant threat to all living things. Most of us are oblivious of this threat because our immune system does a remarkable job of eliminating infectious microbes before they cause symptoms. We are interested in understanding how the immune system detects the presence of infectious microbes. We use all the tools of modern molecular biology, biochemistry, and genetics, to dissect the fundamental mechanisms that provide host defense. We are also interested in understanding the mechanisms by which pathogens evade host immunity and cause disease.