Publications

Primary Publications: 2021

Gaidt MM, Morrow A, Fairgrieve MR, Karr JP, Yosef N, Vance RE. Self-guarding of MORC3 enables virulence factor-triggered immunity (2021) Nature Nov 10. doi: 10.1038/s41586-021-04054-5. Epub ahead of print. PMID: 34759314.

Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, Reja R, Cheung TK, Liang Y, Webster JD, Lehoux I, Skippington E, Reeder J, Haley B, Tan MW, Rose CM, Newton K, Kayagaki N, Vance RE, Dixit VM (2021) Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection. Cell Host Microbe. Oct 13;29(10):1521-1530.e10.

Deets KA, Nichols RD, Rauch I, Vance RE (2021) Pyroptosis-dependent and -independent cross-priming of CD8+ T cells by intestinal epithelial cell-derived antigen. bioRxiv.

Margolis SR, Dietzen PA, Hayes BM, Wilson SC, Remick BC, Chou S, Vance RE (2021) The STING ligand 2’3’-cGAMP induces an NF-κB-dependent anti-bacterial innate immune response in the starlet sea anemone Nematostella vectensis. bioRxiv.

Ji DX*, Witt KC*, Kotov DI, Margolis SR, Louie A, Chévee V, Chen KJ, Dhaliwal HS, Lee AY, Zamboni DS, Kramnik I, Portnoy DA, Darwin KH, Vance RE (2021) Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. Released on bioRxiv 2020. Published eLife Jun 21;10:e67290.

Deets KA, Vance RE (2021) Inflammasomes and adaptive immune responses. Nat Immunol. doi: 10.1038/s41590-021-00869-6. Epub ahead of print. PMID: 33603227. [Review]

Chuang HC, Nichols EK, Rauch I, Chang WC, Lin PM, Misra R, Kitaoka M, Vance RE, Saijo K (2021) Lytic Cell Death in Specific Microglial Subsets Is Required for Preventing Atypical Behavior in Mice. eNeuro 28;8(1) doi: 10.1523/ENEURO.0342-20.2020. PMID: 33414187; PMCID: PMC7877467.

2020

Mitchell PS*, Roncaioli JL*, Turcotte EA, Goers L, Chavez RA, Lee AY, Lesser CF, Rauch I, Vance RE (2020) NAIP–NLRC4-deficient mice are susceptible to shigellosis. Released on bioRxiv May 17, 2020. Published in eLife: https://elifesciences.org/articles/59022

Yamashiro LH, Wilson SC, Morrison HM, Karalis V, Chung J-YJ, Chen KJ, Bateup HS, Szpara ML, Lee AY, Cox JS, Vance RE (2020) Interferon-independent STING signaling promotes resistance to HSV-1 in vivo. Released on bioRxiv Dec 13, 2019. Nat Commun Jul 7;11(1):3382. PMCID: PMC7341812.

Duxbury Z, Wang S, MacKenzie CI, Tenthorey JL, Zhang X, Huh SU, Hu L, Hill L, Ngou PM, Ding P, Chen J, Ma Y, Guo H, Castel B, Moschou PN, Bernoux M, Dodds PN, Vance RE, Jones JDG (2020) Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants. Proc Natl Acad Sci U S A 117(31):18832-18839. PMCID: PMC7414095.

Daskalov A, Mitchell PS, Sandstrom A, Vance RE, Glass NL (2020) Molecular characterization of a fungal gasdermin-like protein. Proc Natl Acad Sci U S A 117(31):18600-18607. doi: 10.1073/pnas.2004876117. PMCID: PMC7414189.

Tenthorey JL, Chavez RA, Thompson TW, Deets KA, Vance RE, Rauch I (2020) NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma. J Exp Med. Jul 6;217(7):e20191736. Released on bioRxiv Sept 18, 2019. PMCID: PMC7336302.

Burke TP, Engström P, Chavez RA, Fonbuena JA, Vance RE, Welch MD (2020)
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis. Nat Microbiol. May;5(5):688-696. PMCID: PMC7239376.

2019

Sandstrom A*, Mitchell PS*, Goers L, Mu EW, Lesser CF, Vance RE (2019) Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Released on bioRxiv May 9, 2018; Published version in Science 364(6435).

Ji DX, Yamashiro LH, Chen KJ, Mukaida N, Kramnik I, Darwin KH, Vance RE (2019) Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra. Nat Microbiol. 2019 Dec;4(12):2128-2135. Epub Oct 14. Released on bioRxiv Aug 10, 2018. PMCID: PMC6879852.

Gonçalves AV, Margolis SR, Quirino GFS, Mascarenhas DPA, Rauch I, Nichols RD, Ansaldo E, Fontana MF, Vance RE, Zamboni DS (2019) Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila. PLoS Pathogens. Jun 28;15(6):e1007886. PMID: 31251782; PMCID: PMC6622555.

Price JV, Russo D, Ji DX, Chavez RA, DiPeso L, Lee AY, Coers J, Vance RE (2019) IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. mBio. Nov 12;10(6):e02629-19. PMID: 31719183; PMCID: PMC6851286.

2018

Marcus A, Mao AJ, Lensink-Vasan M, Wang L, Vance RE, Raulet DH. Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response (2018) Immunity. Oct 16;49(4):754-763.e4. doi:10.1016/j.immuni.2018.09.016. PubMed PMID: 30332631.

Price JV, Jiang K, Galantowicz A, Freifeld A, Vance RE (2018) Legionella pneumophila is directly sensitive to 2-deoxyglucose-phosphate via its UhpC transporter but is indifferent to shifts in host cell glycolytic metabolism. J Bacteriol. May 21. pii: JB.00176-18. doi: 10.1128/JB.00176-18. PMID: 29784886. PMC6060635.

2017

Nichols RD, von Moltke J, Vance RE (2017) NAIP/NLRC4 inflammasome activation in MRP8(+) cells is sufficient to cause systemic inflammatory disease. Nat Commun. 20;8(1):2209.

De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE (2017) Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors. Cell Reports 21(8):2031-2038.

DiPeso L, Ji DX, Vance RE, Price JV (2017) Cell death and cell lysis are separable events during pyroptosis. Cell Death Discov 3:17070.  PMC5682879.

Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE (2017) The structural basis of flagellin detection of NAIP5: a strategy to limit pathogen immune evasion. Science, 358(6365):888-893. PMID: 29146805.

Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE (2017) NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity 46(4):649-659. PMCID: PMC5476318.

Barry KC, Ingolia NT, Vance RE (2017) Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. Elife. Apr 6;6. pii: e22707. PMCID: PMC5407856.

2016

Chavarría-Smith J, Mitchell PS, Ho AM, Daugherty MD, Vance RE (2016) Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation. PLoS Pathogens. Dec 7;12(12):e1006052.

Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE (2016) NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. J. Exp. Med. May 2;213(5):657-65. PubMed Central PMCID: PMC4854734.

Recent Reviews

Dang EV, Madhani HD, Vance RE (2020) Cholesterol in quarantine. Nat Immunol. Jun 8. doi: 10.1038/s41590-020-0712-7. Epub ahead of print. PMID: 32514065.

Haloupek N, Grob P, Tenthorey J, Vance RE, Nogales E (2019) Cryo-EM studies of NAIP-NLRC4 inflammasomes. Methods Enzymol. 2019;625:177-204. Epub 2019 May 24. PMID: 31455527; PMCID: PMC7025759.

Mitchell PS, Sandstrom A, Vance RE (2019) The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries. Curr Opin Immunol. Oct;60:37-45. Epub 2019 May 20. PMID: 31121538; PMCID: PMC6800612.

Sandstrom A, Vance RE (2018) Defusing inflammasomes. J Exp Med 215(3):723-724. doi:10.1084/jem.20180241. Epub 2018 Feb 12. PMID: 29440361.

Margolis SR, Wilson SC, Vance RE (2017) Evolutionary Origins of cGAS-STING Signaling. Trends Immunol. 38(10):733-743. PMID: 28416447.

Vance RE, Eichberg MJ, Portnoy DA, Raulet DH (2017) Listening to each other: Infectious disease and cancer immunology. Sci Immunol. 2(7). PMCID: PMC5927821.

Jones JD, Vance RE, Dangl JL (2016) Intracellular innate immune surveillance devices in plants and animals. Science 354(6316). PMID: 27934708.

Selected earlier publications

Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE (2015). Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling. Molecular Cell. Sep 17;59(6):891-903.

Price JV, Vance RE (2014) The macrophage paradox. Immunity. Nov 20;41(5):685-93.. PubMed PMID: 25517611.

Kranzusch PJ, Lee AS, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA (2014) Structure-guided reprogramming of human cGAS dinucleotide linkage specificity. Cell. Aug 28;158(5):1011-21. 

Tenthorey JL, Kofoed EM, Daugherty MD, Malik HS, Vance RE (2014) Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. Molecular Cell 54(1):17-29.

Chavarría-Smith J, Vance RE (2013) Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor. PLoS Pathogens. 2013 Jun;9(6):e1003452. 

Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE (2013) The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Reports May 30;3(5):1355-61.

Barry KC, Fontana MF, Portman JL, Dugan AS, Vance RE (2013) IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo. J. Immunol May 17.

von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE (2013) Recognition of bacteria by inflammasomes. Annu Rev Immunol. 2013;31:73-106. Epub 2012 Nov 26. PubMed PMID: 23215645.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K & Vance RE (2012) Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature Oct 4;490(7418):107-11. PMCID: PMC3465483.

Ayres JS, Trinidad NJ, Vance RE (2012) Lethal inflammasome activation by a multidrug resistant pathobiont upon antibiotic disruption of the microbiota. Nature Medicine May;18(5):799-806. PMCID: PMC3472005.

Kofoed EM, Vance RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature Aug 28;477(7366):592-5. PMCID: PMC3184209.

Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE (2011) STING is a direct innate immune sensor of cyclic-di-GMP. Nature Sep 25;478(7370):515-8. PMCID: PMC3203314.

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE (2011) The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infection & Immunity Feb;79(2):688-94. Epub 2010 Nov 22.

Fontana MF, Banga S, Barry KC, Shen X, Tan Y, Luo ZQ, Vance RE (2011) Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathogens Feb;7(2):e1001289.

McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, Ishii KJ, Akira S, Colonna M, Chen ZJ, Fitzgerald KA, Hayakawa Y, Vance RE (2009) A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. Journal of Experimental Medicine Aug 31;206(9):1899-911. Epub 2009 Aug 3. PMCID: PMC2737161.

Vance RE, Isberg RR, Portnoy DA (2009) Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe Jul 23;6(1):10-21.

Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE (2008) Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nature Immunology Oct;9(10):1171-8. PMCID: PMC2614210.

Persson J, Vance RE (2007) Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence. Immunogenetics. Oct;59(10):761-78. Epub 2007 Sep 14. Review. PubMed PMID: 17874090

Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE (2006) Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathogens Mar;2(3):e18. Epub 2006 Mar 17. PMCID: PMC1401497.