Publications

2019

Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE (2019) Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Released on Biorxiv May 9, 2018; Published version in Science 364(6435). doi: 10.1126/science.aau1330

2018

Marcus A, Mao AJ, Lensink-Vasan M, Wang L, Vance RE, Raulet DH. Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response. Immunity. 2018 Oct 16;49(4):754-763.e4. doi:10.1016/j.immuni.2018.09.016. PubMed PMID: 30332631.

Ji DX, Chen KJ, Mukaida N, Kramnik I, Darwin KH, Vance RE (2018) Interleukin-1 receptor antagonist mediates type I interferon-driven susceptibility to Mycobacterium tuberculosis. Biorxiv Aug 10 https://doi.org/10.1101/389288

Price JV, Jiang K, Galantowicz A, Freifeld A, Vance RE (2018) Legionella pneumophila is directly sensitive to 2-deoxyglucose-phosphate via its UhpC transporter but is indifferent to shifts in host cell glycolytic metabolism. J Bacteriol. May 21. pii: JB.00176-18. doi: 10.1128/JB.00176-18. PMID: 29784886. PMC6060635.

Sandstrom A, Vance RE (2018) Defusing inflammasomes. J Exp Med 215(3):723-724. doi:10.1084/jem.20180241. Epub 2018 Feb 12. PMID: 29440361.

2017

Nichols RD, von Moltke J, Vance RE (2017) NAIP/NLRC4 inflammasome activation in MRP8(+) cells is sufficient to cause systemic inflammatory disease. Nat Commun. 20;8(1):2209.

De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE (2017) Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors. Cell Reports 21(8):2031-2038.

DiPeso L, Ji DX, Vance RE, Price JV (2017) Cell death and cell lysis are separable events during pyroptosis. Cell Death Discov 3:17070.  PMC5682879.

Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE (2017) The structural basis of flagellin detection of NAIP5: a strategy to limit pathogen immune evasion. Science, 358(6365):888-893. PMID: 29146805.

Vance RE, Eichberg MJ, Portnoy DA, Raulet DH (2017) Listening to each other: Infectious disease and cancer immunology. Sci Immunol. 2(7). PMCID: PMC5927821.

Margolis SR, Wilson SC, Vance RE. Evolutionary Origins of cGAS-STING Signaling. Trends Immunol. 38(10):733-743. PMID: 28416447.

Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE (2017) NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity 46(4):649-659. PMCID: PMC5476318.

Barry KC, Ingolia NT, Vance RE (2017) Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. Elife. Apr 6;6. pii: e22707. PMCID: PMC5407856.

2016

Jones JD, Vance RE, Dangl JL (2016) Intracellular innate immune surveillance devices in plants and animals. Science 354(6316). PMID: 27934708.

Chavarría-Smith J, Mitchell PS, Ho AM, Daugherty MD, Vance RE (2016) Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation. PLoS Pathogens. Dec 7;12(12):e1006052.

Vance RE. Cytosolic DNA Sensing: The Field Narrows (2016) Immunity. Aug 16;45(2):227-8.

Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE (2016) NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. J. Exp. Med. May 2;213(5):657-65. PubMed Central PMCID: PMC4854734.

2015

Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE (2015). Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling. Molecular Cell. Sep 17;59(6):891-903.

Watson RO, Bell SL, MacDuff DA, Kimmey JM, Diner EJ, Olivas J, Vance RE, Stallings CL, Virgin HW, Cox JS (2015) The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. Cell Host Microbe. Jun 10;17(6):811-9. PMCID: PMC4466081.

Chavarría-Smith J, Vance RE (2015) The NLRP1 inflammasomes. Immunol Rev. May;265(1):22-34. PMID: 25879281.

Vance RE. The NAIP/NLRC4 inflammasomes (2015). Curr Opin Immunol. Feb;32:84-9. PMCID: PMC4336817.

Selected earlier publications

Price JV, Vance RE (2014) The macrophage paradox. Immunity. Nov 20;41(5):685-93.. PubMed PMID: 25517611.

Kranzusch PJ, Lee AS, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA (2014) Structure-guided reprogramming of human cGAS dinucleotide linkage specificity. Cell. Aug 28;158(5):1011-21. 

Tenthorey JL, Kofoed EM, Daugherty MD, Malik HS, Vance RE (2014) Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. Molecular Cell 54(1):17-29.

Chavarría-Smith J, Vance RE (2013) Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor. PLoS Pathogens. 2013 Jun;9(6):e1003452. 

Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE (2013) The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Reports May 30;3(5):1355-61.

Barry KC, Fontana MF, Portman JL, Dugan AS, Vance RE (2013) IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo. J. Immunol May 17.

von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE (2013) Recognition of bacteria by inflammasomes. Annu Rev Immunol. 2013;31:73-106. Epub 2012 Nov 26. PubMed PMID: 23215645.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K & Vance RE (2012) Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature Oct 4;490(7418):107-11. PMCID: PMC3465483.

Ayres JS, Trinidad NJ, Vance RE (2012) Lethal inflammasome activation by a multidrug resistant pathobiont upon antibiotic disruption of the microbiota. Nature Medicine May;18(5):799-806. PMCID: PMC3472005.

Kofoed EM, Vance RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature Aug 28;477(7366):592-5. PMCID: PMC3184209.

Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE (2011) STING is a direct innate immune sensor of cyclic-di-GMP. Nature Sep 25;478(7370):515-8. PMCID: PMC3203314.

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE (2011) The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infection & Immunity Feb;79(2):688-94. Epub 2010 Nov 22.

Fontana MF, Banga S, Barry KC, Shen X, Tan Y, Luo ZQ, Vance RE (2011) Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathogens Feb;7(2):e1001289.

McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, Ishii KJ, Akira S, Colonna M, Chen ZJ, Fitzgerald KA, Hayakawa Y, Vance RE (2009) A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. Journal of Experimental Medicine Aug 31;206(9):1899-911. Epub 2009 Aug 3. PMCID: PMC2737161.

Vance RE, Isberg RR, Portnoy DA (2009) Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe Jul 23;6(1):10-21.

Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE (2008) Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nature Immunology Oct;9(10):1171-8. PMCID: PMC2614210.

Persson J, Vance RE (2007) Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence. Immunogenetics. Oct;59(10):761-78. Epub 2007 Sep 14. Review. PubMed PMID: 17874090

Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE (2006) Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathogens Mar;2(3):e18. Epub 2006 Mar 17. PMCID: PMC1401497.